← Impetus Grants

Data for AI to understand aging

Impetus Grants has deployed $34 million to support 146 research projects since 2021. We’re dedicating our next round of grants to generating the open-source data AI needs to understand aging and disease and develop new treatments faster.

Every model needs ground truth data to learn and to test their predictions. For curing disease, the relevant data is not DNA sequences or protein shapes, but molecular changes linked to organ function, disease and treatment outcomes. Collecting these observations takes years, so we need to start now. Our grants will both launch new data collection efforts, and find relevant samples to make AI-ready by adding rich molecular measurements.

We’re raising $15M to fund about 50 projects that generate open source datasets that AI needs to understand aging and develop treatments. The round starts as soon as we're funded.

$9.1M committed, round launches at $15M

Current Patrons

  • Robert Rosenkranz
  • Matt Bell
  • Betty Wold Johnson Foundation
  • Anonymous

Physiology needs its own data

AI impact on a domain depends on three factors: compute, training data and feedback via verification. The data we generate determines where and when AI accelerates progress, and must be relevant to the questions we want to ask.

Goal of these grants: bring relevant disease data forward A conceptual chart shows rapidly rising AI reasoning, slow growth in disease data, and a dashed grant-funded path that begins bending upward at the point marked Funded. A schematic threshold marks the requirements for breakthroughs. The curves are not forecasts. AI reasoning Threshold for breakthroughs Goal ofthese grants Relevant disease data FundedTime Relative availability Goal of these grants: bring relevant disease data forward Conceptual trajectories compare fast-growing AI reasoning with slow-growing disease data. A grant-funded path bends upward from the point marked Funded. AI reasoning Threshold forbreakthroughs Goal ofthese grants Relevant disease data FundedTime Relative availability

AlphaFold learned to predict protein shapes from decades of experimentally measured structures. But predicting shapes doesn't extend to solving disease. Six years after its breakthrough, we still lack a comparable ability to explain and predict how disease unfolds in a whole body. DNA sequences and protein structures don't have blood pressure, heartbeats, or cognitive function. Asking AI how disease happens requires datasets that link molecular changes to organ function, disease progression and treatment outcomes over time. AI needs those observations both to learn and to test its predictions. This type of data involves living organisms and time passing, before we can even consider simulations.

Clinical trials and longitudinal studies have already collected biological samples paired with health outcomes, but often linked to just a couple of clinical readouts. Adding broad profiles of proteins, lipids and metabolites gives AI a depth of biological data to examine interacting processes and find signals that could predict physiological observations. These paired observations can help AI learn how physiological systems work and which details matter, bringing useful disease models closer with less compute. They also let us test predictions against real outcomes and uncover missing biology that could otherwise lead models astray.

Cutaway illustration of a cell

Molecules & Cells

Teaches us rules of biology

Experiments take hours

Automation can scale this

Human torso with internal organs

Organs & Organisms

Teaches us how aging and disease happens

Experiments take months/years

Automation won’t scale this until the 2030s

Start now to get key data sooner

We’ll fund new studies and sample collection now, starting the clock on follow-up that takes months or years and can’t be sped up. We’ll also add rich measurements to stored samples from studies with known health outcomes. That lets us turn years of past observations into AI-ready data much sooner, while new studies begin producing the data needed for continued progress. Some grants will support new methods that let researchers measure more from each sample.

We build datacenters to meet anticipated compute demand. The same logic applies to data.

  • Total data collected
  • AI-ready data
  • Without this round
Recover past data in Year 1, then sustain new collection Schematic of physiological data available over time. Before launch, only a small share of collected data is AI-ready. In Year 1, data from stored samples becomes AI-ready and stays available afterward. New funded collection increases collected and AI-ready data equally. Solid and hatched regions add up to total AI-ready data. Dashed curves show the pace without this round. Amounts and timing are illustrative. Physiological data Underutilizedlongitudinal data Data collected AI-ready data Without this round Past years Roundlaunch Year 1 Year 2 Year 3 Make past samplesAI-ready in Year 1 Recover past data in Year 1, then sustain new collection Schematic of physiological data available over time. Before launch, only a small share of collected data is AI-ready. In Year 1, data from stored samples becomes AI-ready and stays available afterward. New funded collection increases collected and AI-ready data equally. Solid and hatched regions add up to total AI-ready data. Dashed curves show the pace without this round. Amounts and timing are illustrative. Physiological data Underutilizedlongitudinal data Roundlaunch Past years Year 1 Year 2 Year 3 Make past samplesAI-ready in Year 1

Ready to launch

Our grantmaking infrastructure and reviewers in biology and AI are in place. Once commitments reach $15M, we can open applications, review over 1,000 proposals and make awards within 2–3 months.

Open for the field

All funded datasets will be open source, documented and machine-readable so researchers can train and test AI models. The combined output of this round can be cross-referenced by models to verify biological hypotheses.

Relevant examples funded in past rounds

VIBRANT-I

Impetus enabled a 50-woman rapamycin trial for ovarian aging and funded molecular profiling. VIBRANT-II targets 1,000 women.

Primate brain bank

Preserved macaque tissue, blood samples and lifetime health records let researchers study decades of aging now. Impetus funded the bank’s expansion and molecular profiling.

EVERLAST

Impetus added protein and lipid profiling, plus markers of inflammation and senescence, to an NIH-funded everolimus trial. Paired samples link these measurements to physiological responses.

Blood-cell biophysics

Impetus supported a method that measures immune-cell identity, membrane properties and mitochondrial state from human blood. Linking these readouts to disease and molecular profiles yields richer data from each sample.

TIME-seq

TIME-seq makes repeated DNA methylation measurements cheaper by barcoding and sequencing samples together. Impetus funded a longitudinal mouse experiment tracking treatment responses. The published method was also validated in blood from 1,056 people.

Archived brain scans

Existing brain scans from 209 adults let researchers test how receptor binding and brain structure predict age. Impetus funded the analysis.

Impetus' record of fast, efficient, and impactful funding

Since 2021: $34M across 146 projects, supporting 250+ papers and preprints and five clinical trials.

Exceptional work

100x

representation intop journals

~10% of papers published in Nature/Science/Cell, compared to ~0.1% across all papers in that period.

Three-week decisions

Impetus Grants≤3 weeks
NIH R01/R21 scheduled award (More when revisions requested)~43 weeks

Very low overhead

Impetus Grants1.1%
Five comparison funders2.5–4.0%
Manifund, Packard Foundation, Hewlett Foundation, Founders Pledge US and GiveWell. Historical organizational costs, from public tax returns.

Ideas over prestige

Double-blind reviews focus on idea over esteem. Individual reviewers can champion projects without needing committee consensus.

Counterfactual funding

~60% of assessed papers had no NIA support identified.

FAQ

For funders

About this round

Why does this round exist?

AI needs data linking molecular changes to organ function, disease progression and treatment outcomes. Much of that data takes months or years to collect, so we can’t wait until models need it and then catch up.

This round funds new studies that start those observations now, along with molecular measurements of stored samples from studies whose health outcomes are already known. That makes years of past observations useful sooner, while new studies build a growing supply of data.

When will the round launch?

We plan to open applications once total commitments reach $15M. We have $9.1M committed, with $5.9M still to raise.

After reaching the target, we can review proposals and make awards within 2–3 months.

How can I support this round?

To help launch this round sooner, contact Martin Borch Jensen at martin@norn.group. For donations under $5,000, you can donate by card.

Your support helps us fund ambitious science and get it started quickly. Our historical organizational overhead is 1.1%. Recipient institutional overhead is capped at 10%.

How can I contact you?

Please email impetus@norn.group.

What are your EIN and address details?

EIN: 87-1540960

2261 Market Street STE 22725
San Francisco, CA 94114

See additional organization details.

AI and the data

Can AI learn physiology from molecular and cell data alone?

Molecular and cellular data are essential, but the same cell state can produce different outcomes depending on the surrounding tissue and timing. Models need measurements linking those states to organ function, disease progression and treatment response. These paired observations provide training data and real outcomes to test predictions against.

Why start now if automated labs are improving?

Robots can run experiments in parallel, but cannot make organs age faster. Building and deploying them takes time. Even an automated lab needs years of follow-up to observe disease and treatment outcomes. Starting a three-year study today gives us three-year data three years from now.

Couldn’t we simulate disease instead?

Simulations may eventually replace many experiments, but data helps us build them and test their predictions. Models can miss biology we haven’t measured or discovered, and simulating organs over years takes far more compute than simulating cells for minutes. Physiological data helps models learn which details matter, making useful simulations possible sooner and with less compute.

What if AI improves more slowly?

The data will still help researchers study aging and test treatments. Starting slow observations now preserves the option to use stronger models later, while earlier measurements and stored samples can yield useful results sooner.

For researchers

What we fund

What kinds of projects will this round fund?

This round funds projects that create or unlock datasets AI will need to reason about aging and disease. Both new data and more data from existing material count.

New data, for example:

  • High-dimensional measurements added to existing trials and longitudinal studies.
  • Large-scale perturbation experiments in living organisms.
  • Adaptive human trials designed to test AI-generated hypotheses continuously.
  • Measurements of how organs and whole organisms change over time in response to interventions.

More data from existing material, for example:

  • Tools that extract more biology from samples already collected, such as stored blood or tissue.
  • Methods that improve yield from existing biobanks and cohorts, such as the UK Biobank.
  • Harmonization or re-measurement that makes existing data usable for training models.

We look for projects where:

  • The dataset would not be collected otherwise.
  • The data spans interventions, outcomes and/or time courses, so models can learn causal structure.
  • The team designs the dataset for AI use from the start, making it open, documented and machine-readable.
  • The team can deliver the data quickly.
What’s out of scope for a grant?
  • Projects that don’t address this round’s data bottleneck. Good science that AI could already do with existing data is out of scope.
  • Data collection that depends on humanoid robots or general-purpose lab automation that does not yet exist. We fund data that can be generated using today’s methods.
  • Model development, inference tools or analysis platforms without new or newly unlocked data.
  • Standard discovery or mechanism studies whose output is a paper rather than a dataset.
  • Analyzing an existing dataset with new models, unless the analysis itself produces a new, reusable dataset.
Our data comes from an existing trial or cohort. Is that in scope?

Yes. We fund additional measurements of stored samples, as well as harmonization or re-measurement that makes existing data usable for training models.

Analysis with new models is in scope only if it produces a new, reusable dataset.

What project stages do you fund?

We fund projects at any stage, from new ideas to extensions of existing work. The project must produce data that helps AI reason about aging and disease. We are particularly interested in projects that start generating longitudinal data soon.

Do I need preliminary data?

Established methods: If you are applying well-validated measurement approaches to generate a new or more useful dataset, you don’t need preliminary data. Focus on why the dataset matters and how you will structure it.

New methods or hypotheses: If you propose a new measurement approach or explanation of aging, make the case that it is plausible. Preliminary data is one way to do this, but not the only way. You can also cite supporting literature, pilot results or a strong mechanistic rationale.

Do you fund high-risk projects?

We would rather fund the project you are most excited about that could change the field if it works, even if it might fail. We prefer this to work that is certain to produce results but unlikely to move the field forward.

Researchers work within a publishing system that rewards positive results, which can make ambitious projects feel risky. To help funded projects share all their findings, we have previously worked with GeroScience to enable short reports from Impetus-funded projects with null results.

How much funding do you provide?

Our grants range from $10K to $500K. Reviewers consider the amount you request: if two projects are otherwise equal, they will favor the one that needs less funding. On top of your requested amount, we pay institutional overhead of up to 10%.

Can funds be used to pay scientists?

Yes. People are the most essential part of any research project, and usually the most expensive. Feel free to use grant funds for salaries.

What if our plan needs equipment we don’t have?

Using a large fraction of the grant for equipment purchases is not in scope. Plans that depend on tools that have yet to be invented are out of scope.

Applying

Who can apply?

Academic and nonprofit researchers around the world can apply, at any career stage, including trainees and students. Unaffiliated researchers are also eligible. All applicants must have access to the facilities and resources needed for the proposed work.

You don’t need to work in aging biology already. We welcome applicants from other fields whose projects will produce data relevant to aging, disease or treatment outcomes.

Do you fund companies?

No, we do not fund for-profit efforts.

How do I apply, and how are proposals reviewed?

We review applications in three stages so we can handle a large volume of proposals.

  1. Short proposal. Submit about three paragraphs describing your idea. Longevity experts check that each proposal fits the round’s goals and could be impactful if successful.
  2. Detailed plan. Shortlisted applicants submit 1–2 pages describing how they will carry out the work and their goals and plans for open-source datasets. A biologist and a machine learning researcher review each proposal. Sometimes an expert in the proposed method also reviews it. They assess technical feasibility, whether the scientific plan is sound for the intended outcomes, and whether the proposed data structure suits use in AI models.
  3. Interview. Applicants we don’t already know have a fifteen-minute chat with Impetus Grants founder Martin Borch Jensen.

You can access the Stage 1 application [application link].

When will I hear back about my application?

For Round 4, we aim to give every applicant a final funding decision within five weeks of receiving their application.

The three-week figure elsewhere on this page describes Impetus’s historical decision timeline.

What is the project period?

We don’t set a fixed project period. Propose whatever timeline your project realistically needs, and explain it in your application if necessary. We favor proposals that deliver results sooner.

Can applicants submit multiple proposals?

Yes, you can submit multiple proposals. Each applicant can receive up to $500K in total across Round 4 awards, including awards as a co-applicant.

Does Impetus Grants fund collaborative projects?

Yes, you can include co-applicants. If we fund your project, we pay the grant to the lead applicant’s institution, which can subgrant part of it to a co-applicant’s institution.

Will my proposal be confidential?

Yes. All our staff and reviewers sign a non-disclosure agreement, which you can read [NDA link].

Does “other funding” refer only to active grants?

Please disclose both active and pending grants in the “other funding” section.

After an award

Can we embargo our data while we publish?

Yes, for a short period. We understand that you may want to publish your findings first. Because this round aims to get data into the hands of AI researchers quickly, release your dataset publicly no later than when you post your preprint, and in any case within six months of the end of the grant period.

If your data involves human participants, you can use controlled-access repositories where privacy rules require them. We can agree a longer timeline if repository review requires it, but favor earlier releases. Describe your data release plan in your application. We will not fund proposals that leave doubts about data sharing.

What are my responsibilities as a researcher?

Do your best work!

When you accept a grant, you and your institution also agree to the following:

Use of funds: Use the funds only for the project, broadly as described in your proposal. The grant runs from the start date to the end date set out in your proposal.

Record-keeping: Keep adequate records showing that you used the funds for the project as proposed. We may inspect these records.

Progress reports: We pay the grant in several installments. Before each payment, submit a short progress report covering the previous period. If a report is late or unsatisfactory, we may delay or withhold the next payment.

Compliance: Follow all applicable laws and regulations, including IBC and IACUC requirements.

Preprints: Post your work as a public preprint (for example, on bioRxiv) as soon as it’s ready, and no later than when you submit it to a journal. We want your findings to reach the field without delay.

Detailed protocols: Include protocols in every publication that go well beyond a standard methods section. At a minimum, include:

  • All sequences used.
  • All code and software, with versions and licenses.
  • Exact reagent quantities, manufacturers and batch numbers.
  • Kit and instrument details.
  • Anything else a third party would need to replicate the work.

We may treat failure to provide these as a breach of the grant agreement.

Acknowledgment: Include the following statement in all outputs, including preprints, papers, talks and posters: “The project was supported by a Longevity Impetus Grant from Norn Group.”

The agreement you will sign if you receive a grant describes these requirements in greater detail.

Who owns IP from funded projects?

You and your institution do, subject to your institution’s own policies. Norn Group makes no claim on intellectual property of any kind.

Can I negotiate the grant agreement or institutional overhead rate?

No. We use the same agreement and overhead rate for every grantee. We cannot change the wording of the agreement or pay more than 10% overhead.

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